Medical Technology

NADHJA® lab355

The NADHJA® lab 355 is a high-quality, innovative laboratory instrument. It allows the analysis of autofluorescence of the reduced form of the metabolic enzyme NAD (nicotinic adenine dinucleotide) in a very precisely defined tissue volume after excitation by UV laser pulses.  Fluorescence excitation is achieved by the nanosecond pulse of a frequency tripled Nd:YAG laser at a wavelength of 355 nm. The detection of the fluorescence is performed by a photomultiplier and signal amplifier. The use of special fiber optic probes allows a wide range of applications.

With the NADHJA® lab 355 it is possible for the first time to measure NADH concentration changes in tissue continuously, invasively or non-invasively, in real time by laser-induced autofluorescence. Therefore, no separate fluorescence marker is necessary for the measurement.

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Application areas

• Analysis/measurement of NADH concentration in cell metabolism.
• Monitoring of cellular oxygen demand
• demand-based oxygen monitoring
• Analysis of the cellular activity of oxygen deficiency states
• Detection of cell pathological disorders of cell metabolism.

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Research areas

• Metabolic Research
• Cancer Research
• Heart / Circulatory diseases
• Diabetes Research
• Neurological diseases
• in vitro monitoring of cell vitality
• Pharmacology / Toxicology

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You can find detailed information in our flyer. We would be happy to demonstrate the device to you free of charge. Please make an appointment with us.
We will explain the functions and set up the device so that you can use it without any problems.

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Laser optical methods in biomedical analytics

Laser dissection for cell surgery

Cut cell components out of the living cell with ultrashort laser pulses

Using laser pulses from a femtosecond laser, we can cut out individual cell organelles, such as mitochondria, from vital cells. The great advantage of this is that the cell organelles are not destroyed in their structure and thus, unlike conventional methods, experience no or only minor changes in the molecular structure; i.e., the results are considerably more plausible, better validated and thus significantly safer.

In contrast to conventional processes, this can reduce costs and effort. This results in a wide range of new sophisticated application possibilities.

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Laser optoporation

perforate the cell membrane with ultrashort laser pulses

Using laser pulses from a femtosecond laser, we can open the cell membrane of individual cells or cell layers selectively and temporarily. This allows, for example, the transfer of DNA or the introduction of other molecules into defined cells. Following optoporation, these cells can be tested for their vitality and propagated.

In contrast to conventional processes, this can reduce costs and effort. This results in a multitude of new and sophisticated application possibilities.